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Doctors have depended on tacrolimus to help prevent rejection for about 20 years; it is the most commonly used anti-rejection medicine (also called an immunosuppressant) in the US.

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In this study, we evaluated the pharmacokinetics and CaN activity in peripheral blood mononuclear cells after oral administration of a conventional tacrolimus formulation to clarify the significance of trough monitoring of tacrolimus blood concentration during the early post-transplantation phase of living-donor liver transplantation (LDLT).

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Data were analyzed for 97 adults treated in a multicenter trial of tacrolimus and methotrexate or methylprednisolone as GVHD prophylaxis after unrelated donor marrow transplantation.

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In this study, patients receiving Tacrolimus QD had whole-blood trough levels within the therapeutic window while having lower tacrolimus exposure immediately posttransplant when compared with Tacrolimus BID.

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