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How long does it take metoprolol to leave your system? It slows down your heart rate and makes it easier for your heart to pump blood around your body. Metoprolol starts to work after about 2 hours, but it can take up to 1 week to fully take effect.
Should I take my blood pressure medicine in the morning or at night? Blood pressure shows a 24-hour rhythm, higher during the day and lower during nighttime sleep. However, especially after age 55, many people with high blood pressure don't exhibit this nighttime dip, a condition called non-dipping. When to take medicine : Take at least one blood pressure -lowering medication at bedtime.